Optimizing Parameters to Display Protein Dynamics of Cyclophilin A Through Phenix Ensemble Refinement

Abstract: Current x-ray crystallography techniques used to image proteins represent molecules as rigid,  single-state structures. While widely used and effective, these techniques fail to account for the molecular dynamics of protein solution states, which can obstruct complete understanding of protein function. Through Kinetic Ensemble Refinement, the molecular motion of protein structures can be captured as … Read more