Summer Research 2021 Poster Session
Summer 2021
Abstract: Allosteric signaling, the phenomenon of an effector molecule to modulate the activity at a distal active site, has been known for some half a century in molecules such as proteins. However, how that signal is transmitted remains a debated topic. One method posited to identify a network of residues transmitting the signal is sector … Read more
Abstract: The Free Energy Landscape (FEL), a representation of the energetic configurational space underlying the thermodynamics and kinetics of any molecular process, can be used to describe the conformational substate selection processes of molecules. Therefore in the case of a mutated molecule, if the FEL can be restored to an active state, a major challenge … Read more
Abstract: The p53 gene acts as a tumor suppressor by inducing growth arrest or apoptosis during the cell cycle. Mutations of p53 are responsible for about half of all human cancers. Extensive research has been done on the resulting protein and, more specifically, the protein’s DNA binding domain. Humans have nine isoforms of p53: the … Read more