Molecular Dynamics Simulations of the Isoforms of p53

Isabel Armour-Garb
Isabel Armour-Garb

Isabel is a rising senior (’22) majoring in Computer Science and Mathematics with a minor in Informatics and Modeling. She is from Albany, NY, and she graduated from Bethlehem Central High School. At Wesleyan, Isabel is involved with Triple Major a cappella, the Wesleyan University Middle School Tutoring Partnership, and the Scientific Computing and Informatics Center. She hopes to continue studying bioinformatics after graduating.

Abstract: The p53 gene acts as a tumor suppressor by inducing growth arrest or apoptosis during the cell cycle. Mutations of p53 are responsible for about half of all human cancers. Extensive research has been done on the resulting protein and, more specifically, the protein’s DNA binding domain. Humans have nine isoforms of p53: the full-length wildtype, and eight splice variants that contain portions of the tails. Most existing studies focus exclusively on the wildtype and its DNA binding domain, often leaving out the tails of the wildtype and the eight other isoforms. My research serves to explore the behavior of the full-length wildtype p53 and its isoforms to learn about their potential regulatory effects.

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