Kinetics of Heptosyltransferase I and Identification of Potential Inhibitors
Abstract: Lipopolysaccharides are an essential component of the membrane of gram-negative bacteria, which cause a multitude of diseases such as cholera and influenza. Inhibiting lipopolysaccharide production by targeting a key enzyme in its synthetic pathway, Heptosyltransferase I, has been shown to increase bacterial susceptibility to antibiotics. Previously in the Taylor lab, 419 compounds were computationally … Read more