Neurosteroidogenesis and Individual Differences in Vulnerability to Developing Escalated Alcohol Intake Following Chronic Social Defeat Stress
Post-traumatic stress disorder (PTSD) is one of the most prevalent co-occurring psychiatric pathologies among individuals with alcohol use disorder (AUD). Although comorbidity worsens the symptoms and prognosis following treatment of both disorders, no approved compound has demonstrated efficacy to treat AUD comorbid with PTSD. GABAergic neurosteroids are altered by chronic alcohol and play a role … Read more